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KMID : 0370219740180040236
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Yakhak Hoeji
1974 Volume.18 No. 4 p.236 ~ p.242
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Effects of Some Factors on the Preparation of Spherical Particles by Extrusion-spheronization Processing. I
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이강춘/Lee KC
민신홍/이상희/김용배/이철우/Min SH/Rhee SH/Kim YB/Lee CW
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Abstract
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Extrusion-spheronization processing combination was used to produce spherical granules with experimental formulations which contain microcrystalline cellulose as a diluent. The produced granules were compared on the basis of the following physical properties; (a) particle size distribution, (b) repose angle, (c) granule density, (d) bulk density, (e) porosity, (f) friability and (g) dissolution rate. With the specific experimental formulations used in this study, the increased plate rotational speeds of Marumerizer (400-1200rpm) produced continually more spherical material and also the obtained data indicated that the particle size distribution and dissolution rate depend upon the amount of microcrystalline cellulose used. As a result, the spherical granule preparation with microcrystalline cellulose has good properties in flow rate, packing property and friability and offers a suitable method of granule preparation in pharmaceutical industry.
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KEYWORD
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